You have to consider that it's highly unlikely that everyone in CA would be in favor of secession. I can imagine that many people in the Central Valley, who tend to be far more conservative than their coastal counterparts and rely extensively on Federal farm subsidies as well as out of state water resources would be less than thrilled at the idea. These people also tend to have high rates of firearms ownership so I could see a nice little insurgency springing up.

Certainly there is a lot of high tech industry in CA but I doubt that Lockheed and the other defense corps are disproportionately reliant on CA, they have plants and R&D centers spread throughout the country.

I agree it's something interesting to ponder.