I think you may be confused about what "throughput-optimized" means. HFT is not throughput-optimized by definition. The LMAX link literally says it is a latency-optimized system. An optimal throughput-optimized system has unbounded worst-case latency -- the opposite of "latency-optimized".
None of those links contradict anything I wrote, I am already familiar with all of them.
https://www.lmax.com/exchange/technology
No, you could not guide battleship weapons in Javascriptt
https://www.lockheedmartin.com/en-us/products/aegis-combat-s...
https://dl.acm.org/doi/abs/10.1145/2402709.2402699
And no they don't disable the GC, they have real time GC implementations,
https://www.ptc.com/en/products/developer-tools/perc